The intestinal microflora controls the metabolism of glucose
Scientists from Oregon State University found the relationship of the immune system and intestinal microflora with glucose metabolism. This interaction is an important aspect in the risk of developing type 2 diabetes and metabolic syndrome. The study showed the role of intestinal bacteria, especially the bacteria Akkermansia muciniphila, involved in the metabolism of glucose. It became clear that our immune system is closely related to metabolic functions, and this new area of research is called immunometabolism. It turned out that in the process of evolution, human beings had functional systems, in which microbes are an important and integral part. It is known that the signal protein interferon gamma affects the metabolism of glucose, helps fight infections, and it turned out that in this process, the important role of A. muciniphila bacteria. The line of laboratory mice specially designed for this study with a lower level of gamma-interferon had a higher level of A. muciniphila, and increased tolerance to glucose. If the amount of interferon they increased, immediately lowered the level of A. muciniphila, and decreased tolerance to glucose. These results have been confirmed in humans. It was noted that athletes with a higher body weight have a high level of A. muciniphila intestinal bacteria. This study showed that the immunity and metabolism of glucose are closely related, and the bridge between them are intestinal bacteria.
The results of this work can lead to a new “probiotic” approach in the treatment of diabetes and metabolic syndrome.