Vaccines for caries and periodontitis
Results of the work of Chinese scientists who created a vaccine against caries published In the journal Scientific Reports. The reason for the development of caries is the bacteria living in the oral cavity of Streptococcus mutans. These microbes secrete lactic acid, leading to the formation of calculus that destroys the tooth enamel. The idea of a vaccine against caries was hatched for a long time and finally experiments on laboratory animals are over and soon the vaccine will undergo clinical trials. The vaccine uses a hybrid two-component protein KF-rPAc. The KF protein elicits an immune response to the rPAc protein located on the surface of the Streptococcus mutans membrane. In this case, the bacteria undergo a powerful immune attack. But Australian scientists are working to create a vaccine that prevents periodontitis. This vaccine targets enzymes produced by the bacterium Porphyromonas gingivalis. As a result, antibodies are produced that neutralize the toxins of this bacterium. Clinical trials of this vaccine will be conducted In 2018.